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IMPS - Invalid Metabolic Panaceas & Improbable Leads

What are IMPS?

The existence of compounds with reported bioactivity for virtually any biological/pharmacological endpoint was demonstrated in 2016 in the following publication:

Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF
Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
Journal of Medicinal Chemistry 59: 1671-1690 (2016)
dx.doi.org/10.1021/acs.jmedchem.5b01009
PubMedCentral: PMC4791574 [Open Access Article]

Termed Invalid Metabolic Panaceas, most IMPS are present in natural sources in relatively high abundance and represent largelyu over-studied and over-reported compounds.

Analytical Data Sets IMPS

In order to facilitate the unambiguous identification of IMPS, full sets of analytical data are being acquired by the Center for Natural Product Technologies (CENAPT) at UIC.

Annotated and Raw NMR Data Sets of IMPs

This data is published on the CENAPT Raw NMR Data Dataverse at https://dataverse.harvard.edu/dataverse/cenapt. The following raw and and annotaed IMP NMR datasets are available:

 

 

IMPS Part I :
How IMPs can undermine Natural Product-Based Drug Discovery

Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
J. Med. Chem. 59: 1671-90 (2016) ResComplx Ser#28

 
   

IMPS Part II:
The Essential Medicinal Chemistry of Curcumin

K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
The Essential Medicinal Chemistry of Curcumin
Journal of Medicinal Chemistry 60, 1620 (2017)
LTTE:
ACS Medicinal Chemsitry Letters, 8, 467-470

Open Access Article Altmertics Statistics
Report in Nature
ACS Editorial in PAINS and IMPS

 
   

IMPS Part I :
How IMPs can undermine Natural Product-Based Drug Discovery

Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
J. Med. Chem. 59: 1671-90 (2016) ResComplx Ser#28

 
   
   
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