Guido Pauli Natural Products Science and Research at UIC Chicago

Overview

Natural metabolites from sources across the phylogenetic tree of organisms play an important role in pharmacy, physiology, biochemistry, pharmacology, drug discovery, and medicine. The separation, chemical analysis, (semi-)synthesis, pharmacological and in vivo biological evaluation are core elements of contemporary biomedical research including the highly interdisciplinary fields of pharmacognosy and medicinal chemistry.
Gaining a more holistic insight into the natural complexity of an organism's total pool of metabolites (metabolome) requires the development of innovative (bio)-analytical and chemical methodology. To this end, our laboratory advances loss-free and high-resolution countercurrent separation and parition chromatography (CCS/CCC/CPC). Moreover, we continue to pioneer the development of quantitative NMR (qNMR) in pharmaceutical, chemical, food, and natural product analysis. Generally, we develop innovative spectroscopic (NMR, hyphenated MS, ECD) and computational methods (quantum mechanical tools in NMR) for the characterization of drug leads.
Solving analytical puzzles continues to be a challenge for both natural metabolites and synthetic active pharmaceutical ingredients (APIs) that constitute 'small molecules'. These typically organic compounds make up a vast portion of the chemical space of nature and drug molecules. To ehance such knowledge essential for human health, we design innovative separation technology and spectroscopic methods to be used for structural analysis, the determination of purity, and the recognition of residual complexity. Combined with qualitative and quantitative chemical analysis and in-depth biological evaluation evaluation of bioactive principles, our research contributes to drug discovery in tuberculosis and dentistry. Our bio-analytical contributions help advance interdisciplinary research projects, create new insights of biomedical relevance, and impact the practice and evolving paradigms of healthcare and biomedical research.

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Mission

Approach

Publications

Research Etc Links

Overview



	Mission Gain better understanding of the small molecules that impact health and guide life on Earth Approach Trans-disciplinary integration and innovation of natural products chemistry and pharmaceutical analysis in drug discovery, dietary supplements, and traditional medicine research Publications Publications\|DOIs & Links Publication Data\|Dataverse Research Topics\|Pub Topics Presentations\|AV Media Research Etc Links Dental Biomaterials & Plants\|CENAPT qNMR\|Quantitative NMR HiFSA\|HiFSA-qNMR\|QM-qHNMR qNMR Calculations qNMR Summits\|Put-q-into-NMR Botanical Center Botanical Reference\|qREF Residual Complexity IMPs w/NMRdata\|Invalid Metabolic Panaceas Dreiding Exchange\|Model Kits Countercurrent Separation CCS/CCC/HSCCC/CPC Pharmagonosy Institute NAPRALERT\|NCI PDQ WHOTRMCC\|PHO Ontology Lab Safety T32 K12\|Research Training Farnsworth Lectures Atkins Garden\| Garden Walk Jobs Photo Galleries	Overview Natural metabolites from sources across the phylogenetic tree of organisms play an important role in pharmacy, physiology, biochemistry, pharmacology, drug discovery, and medicine. The separation, chemical analysis, (semi-)synthesis, pharmacological and in vivo biological evaluation are core elements of contemporary biomedical research including the highly interdisciplinary fields of pharmacognosy and medicinal chemistry. Gaining a more holistic insight into the natural complexity of an organism's total pool of metabolites (metabolome) requires the development of innovative (bio)-analytical and chemical methodology. To this end, our laboratory advances loss-free and high-resolution countercurrent separation and parition chromatography (CCS/CCC/CPC). Moreover, we continue to pioneer the development of quantitative NMR (qNMR) in pharmaceutical, chemical, food, and natural product analysis. Generally, we develop innovative spectroscopic (NMR, hyphenated MS, ECD) and computational methods (quantum mechanical tools in NMR) for the characterization of drug leads. Solving analytical puzzles continues to be a challenge for both natural metabolites and synthetic active pharmaceutical ingredients (APIs) that constitute 'small molecules'. These typically organic compounds make up a vast portion of the chemical space of nature and drug molecules. To ehance such knowledge essential for human health, we design innovative separation technology and spectroscopic methods to be used for structural analysis, the determination of purity, and the recognition of residual complexity. Combined with qualitative and quantitative chemical analysis and in-depth biological evaluation evaluation of bioactive principles, our research contributes to drug discovery in tuberculosis and dentistry. Our bio-analytical contributions help advance interdisciplinary research projects, create new insights of biomedical relevance, and impact the practice and evolving paradigms of healthcare and biomedical research.






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