of the small molecules of
life on Earth.
CENAPT|Center for Natural Product Technologies
qREF|Botanical Reference Materials
Dreiding Exchange|Model Kits
Countercurrent Separation CCS/CCC/HSCCC/CPC
CCC 2016|The CCS Conference
Publications|DOIs & Links
Publication Data| Dataverse
Research Topics| Pub Topics
metabolites from natural sources across the phylogenetic tree have always
played an important role in physiology, biochemistry, pharmacology, drug
discovery and pharmaceutical analysis. Their separation,
analysis and pharmacological evaluation
are core elements of modern pharmacognosy,
representing an interdisciplinary field of research.
Gaining a more holistic insight into the
overwhelming complexity of the total pool of secondary metabolites produced
by any single organism (metabolome)
requires development of innovative (bio)-analytical methodology, such as loss-free and high-resolution countercurrent separation and chromatography (CCS/CCC), quantitative
NMR (qNMR), and other innovative spectroscopic (NMR, LC/GC-MS) as well as computational methods developed in our laboratory.
This requirement continues
to hold for those metabolites that today are classified as 'small molecules',
which open the door to an incredibly large and very important part of
nature's chemical space. The design of innovative separation technology and spectroscopic methods for structural analysis and determination of purity and residual complexity,
combined with qualitative and quantitative analysis of bioactive principles and their in-depth biological
evaluation, are important aspects of secondary metabolome
research. Such bio-analytical contributions can advance interdisciplinary research projects and create new insights of biomedical relevance, which can impact current practice and future paradigms in contemporary healthcare research.