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Dental Biomaterials & Plants

Plant-Based Solutions Improve Tooth Repair - The Dentistry-Pharmacy Collaborative

The COD-COP Project

Summary. This trans-disciplinary project explores and develops the use of plant tannins, particularly oligomeric proanthocyanidins (OPACs), as agents that enhance the biomechanical properties of a collagenous core tissue of teeth (dentin) and have potential as new agents in restorative dentistry.

The COD-COP Team

Collaborating since 2008, the research team involved the groups of


R Phansalkar, J-W Nam, A Leme-Kraus, L-S Gan, B Zhou, J McAlpine, S-N Chen,
A Bedran-Russo, G Pauli
Proanthocyanidin Dimers and Trimers from Vitis vinifera Provide Diverse Structural Motifs for the Evaluation of Dentin Biomodification
Journal of Natural Products 82, 2387-2399 (2019)
Raw Data [Dataverse]:
PubMedCentral: PMC in process [NIHMSID 1039986]

B Aydin, A Leme-Kraus, C Vidal, T Aguiar, R Phansalkar, JW Nam, J McAlpine, SN Chen,
G Pauli, A Bedran-Russo
Evidence to the role of interflavan linkages and galloylation of proanthocyanidins at sustaining long-term dentin biomodification
Dental Materials
35, 328-334 (2019)

PubMedCentral: PMC6346742

R Phansalkar, JW Nam, SN Chen, J McAlpine, A Leme, B Aydin, AK Bedran-Russo, G Pauli
Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development
Journal of Chromatography A 1535, 55-62 (2018)
Raw Data [Dataverse]:
PubMedCentral: PMC5801063

D Kulakowski, A Leme-Kraus, J-W Nam, J McAlpine, S-N Chen, G Pauli, S Ravindran,
A Bedran-Russo
Oligomeric proanthocyanidins released from dentin induce regenerative dental pulp cell response
Acta Biomaterialia 55, 262-270 (2017)
Raw Data [Dataverse]:
PubMedCentral: PMC5504470

A Leme, B Aydin, C Vidal, R Phansalkar, J-W Nam, J McAlpine,
G Pauli, S-N Chen, A Bedran-Russo
Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies
Journal of Dental Research 96, 406-412 (2017)
PubMedCentral: PMC5384485

JW Nam, R Phansalkar, D Lankin, J McAlpine, A Leme-Kraus, C Vidal, A Bedran-Russo, S-N Chen, G Pauli
Absolute Stereochemistry of Native Oligomeric Proanthocyanidins with Dentin Biomodification Potency
Journal of Organic Chemistry 82, 1316-1329 (2017)
Raw Data [Dataverse]:
PubMedCentral: PMC in progress
[Featured in C&E News, March 2017: "Bark Extract Strengthens Bite "]

G Kim, A Leme, B Aydin, R Phansalkar, JW Nam, G Viana, C Wu,
S-N Chen, G Pauli, A Bedran-Russo
Effect of bioactive primers on bacterial-induced secondary caries at the tooth-resin interface
Operative Dentistry 42, 196-202 (2017)
PubMedCentral: PMC5976884

Nam JW, Phansalkar R, Lankin D, Bisson J, McAlpine J, Leme A, Vidal C, Ramirez B, Niemitz M, Bedran-Russo A, Chen SN, Pauli GF
Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency
Journal of Organic Chemistry 80: 7495-7507 (2015)
PubMedCentral: PMC4537297

Phansalkar R, Nam J-W, Chen, S-N, McAlpine, JB, Napolitano JF, Leme A, Vidal C, Aguiar T, Bedran Russo A, Pauli GF
A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential
Fitoterapia 101: 169-178 (2015)

PubMedCentral: PMC4346468

Vidal C, Leme A, Aguiar T, Phansalkar R, Nam JW, Bisson J, McAlpine J, Chen SN, Pauli GF, Bedran-Russo A
Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids
Langmuir 30: 14887-14893 (2014)

PubMedCentral: PMC4437200

Vidal C, Aguiar T, Phansalkar R, McAlpine J, Napolitano J, Chen SN, Araujo L, Pauli GF, Bedran-Russo A
Galloyl Moieties Enhance the Dentin Biomodification Potential of Plant-derived Catechins
Acta Biomaterialia 10: 3288-3294 (2014)

PubMedCentral: PMC4041811

Aguiar T, Vidal C, Phansalkar R, Todorova I, Napolitano J, McAlpine J, Chen SN, Pauli G, Bedran-Russo A
Dentin Biomodification Depends on Polyphenol Source
Journal of Dental Research 93: 417-422 (2014)

PubMedCentral: PMC3957344

Bedran-Russo A, Pauli G, Chen SN, McAlpine J, Castellan C, Phansalkar R, Aguiar T, Vidal C, Napolitano J, Nam JW, Leme A
Dentin biomodification: Strategies, renewable resources and clinical applications
Journal of Dentistry 30: 62-76 (2014)

PubMedCentral: PMC3972923

Castellan C, Pereira P, Viana G, Chen SN, Pauli GF, Bedran-Russo A
Solubility study of phytochemical cross-linking agents on dentin stiffness
Journal of Dentistry 38: 431-436 (2010)






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