Publication Series: Residual Complexity of Bioactive Natural Products


		Dental Biomaterials & Plants Plant-Based Solutions Improve Tooth Repair - The Dentistry-Pharmacy Collaborative The COD-COP Project Summary. This trans-disciplinary project explores and develops the use of plant tannins, particularly oligomeric proanthocyanidins (OPACs), as agents that enhance the biomechanical properties of a collagenous core tissue of teeth (dentin) and have potential as new agents in restorative dentistry. The COD-COP Team Collaborating since 2008, the research team involved the groups of Dr. Ana Bedran-Russo in the UIC College of Dentistry Dr. Guido Pauli in the UIC College of Pharmacy Publications 14 R Phansalkar, J-W Nam, A Leme-Kraus, L-S Gan, B Zhou, J McAlpine, S-N Chen, A Bedran-Russo, G Pauli Proanthocyanidin Dimers and Trimers from Vitis vinifera Provide Diverse Structural Motifs for the Evaluation of Dentin Biomodification Journal of Natural Products 82, 2387-2399 (2019) dx.doi.org/10.1021/acs.jnatprod.8b00953 *Raw Data* [Dataverse]: dx.doi.org/10.7910/DVN/EF1FWQ PubMedCentral: PMC in process [NIHMSID 1039986] 13 B Aydin, A Leme-Kraus, C Vidal, T Aguiar, R Phansalkar, JW Nam, J McAlpine, SN Chen, G Pauli, A Bedran-Russo Evidence to the role of interflavan linkages and galloylation of proanthocyanidins at sustaining long-term dentin biomodification Dental Materials 35, 328-334 (2019) doi.org/10.1016/j.dental.2018.11.029 PubMedCentral: PMC6346742 12 R Phansalkar, JW Nam, SN Chen, J McAlpine, A Leme, B Aydin, AK Bedran-Russo, G Pauli Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development Journal of Chromatography A 1535, 55-62 (2018) dx.doi.org/10.1021/10.1016/j.chroma.2017.12.050 Raw Data [Dataverse]: dx.doi.org/ PubMedCentral: PMC5801063 11 D Kulakowski, A Leme-Kraus, J-W Nam, J McAlpine, S-N Chen, G Pauli, S Ravindran, A Bedran-Russo Oligomeric proanthocyanidins released from dentin induce regenerative dental pulp cell response Acta Biomaterialia 55, 262-270 (2017) doi.org/10.1016/j.actbio.2017.03.051 Raw Data [Dataverse]: dx.doi.org/ PubMedCentral: PMC5504470 10 A Leme, B Aydin, C Vidal, R Phansalkar, J-W Nam, J McAlpine, G Pauli, S-N Chen, A Bedran-Russo Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies Journal of Dental Research 96, 406-412 (2017) dx.doi.org/10.1177/0022034516680586 PubMedCentral: PMC5384485 9 JW Nam, R Phansalkar, D Lankin, J McAlpine, A Leme-Kraus, C Vidal, A Bedran-Russo, S-N Chen, G Pauli Absolute Stereochemistry of Native Oligomeric Proanthocyanidins with Dentin Biomodification Potency Journal of Organic Chemistry 82, 1316-1329 (2017) dx.doi.org/10.1021/acs.joc.6b02161 Raw Data [Dataverse]: dx.doi.org/ PubMedCentral: PMC in progress [Featured in C&E News, March 2017: "Bark Extract Strengthens Bite "] 8 G Kim, A Leme, B Aydin, R Phansalkar, JW Nam, G Viana, C Wu, S-N Chen, G Pauli, A Bedran-Russo Effect of bioactive primers on bacterial-induced secondary caries at the tooth-resin interface Operative Dentistry 42, 196-202 (2017) dx.doi.org/10.2341/16-107-L PubMedCentral: PMC5976884 7 Nam JW, Phansalkar R, Lankin D, Bisson J, McAlpine J, Leme A, Vidal C, Ramirez B, Niemitz M, Bedran-Russo A, Chen SN, Pauli GF Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency Journal of Organic Chemistry 80: 7495-7507 (2015) dx.doi.org/10.1021/acs.joc.5b01082 PubMedCentral: PMC4537297 6 Phansalkar R, Nam J-W, Chen, S-N, McAlpine, JB, Napolitano JF, Leme A, Vidal C, Aguiar T, Bedran Russo A, Pauli GF A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential Fitoterapia 101: 169-178 (2015) dx.doi.org/10.1016/j.fitote.2014.12.006 PubMedCentral: PMC4346468 5 Vidal C, Leme A, Aguiar T, Phansalkar R, Nam JW, Bisson J, McAlpine J, Chen SN, Pauli GF, Bedran-Russo A Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids Langmuir 30: 14887-14893 (2014) dx.doi.org/10.1021/la5034383 PubMedCentral: PMC4437200 4 Vidal C, Aguiar T, Phansalkar R, McAlpine J, Napolitano J, Chen SN, Araujo L, Pauli GF, Bedran-Russo A Galloyl Moieties Enhance the Dentin Biomodification Potential of Plant-derived Catechins Acta Biomaterialia 10: 3288-3294 (2014) dx.doi.org/10.1016/j.actbio.2014.03.036 PubMedCentral: PMC4041811 3 Aguiar T, Vidal C, Phansalkar R, Todorova I, Napolitano J, McAlpine J, Chen SN, Pauli G, Bedran-Russo A Dentin Biomodification Depends on Polyphenol Source Journal of Dental Research 93: 417-422 (2014) dx.doi.org/10.1177/0022034514523783 PubMedCentral: PMC3957344 2 Bedran-Russo A, Pauli G, Chen SN, McAlpine J, Castellan C, Phansalkar R, Aguiar T, Vidal C, Napolitano J, Nam JW, Leme A Dentin biomodification: Strategies, renewable resources and clinical applications Journal of Dentistry 30: 62-76 (2014) dx.doi.org/10.1016/j.dental.2013.10.012 PubMedCentral: PMC3972923 1 Castellan C, Pereira P, Viana G, Chen SN, Pauli GF, Bedran-Russo A Solubility study of phytochemical cross-linking agents on dentin stiffness Journal of Dentistry 38: 431-436 (2010) dx.doi.org/10.1016/j.jdent.2010.02.002














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