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Publications

Peer-reviewed articles and book chapters with DOI links and PMC Links. PubMedCentral (PMC) is an open-access repository of articles that received NIH funding; note there is a 12-month waiting period (search PMC for our deposited articles). For educational and scholarly activity, you can request reprints directly from the author.

gfp@uic.edu Publication Dataverse

A separate page provides Links to Original ("Raw") Electronic Data related to the publications; individual links are included in the List of Publications below.

List of Publications

2017top of list|by year ]

184
S Warit, K Rukseree, T Prammananan, P Hongmanee, P Billamas, S Jaitrong, A Chaiprasert, B Jaki, G Pauli, S Franzblau, P. Palittapongarnpim
In Vitro Activities of Enantiopure and Racemic 1′-Acetoxychavicol Acetate against Clinical Isolates of Mycobacterium tuberculosis
Scientia Pharmaceutica
85, 32 (2017)
dx.doi.org/xyz
PubMedCentral: PMC in progress

183
JB Friesen, J McAlpine, SN Chen, G Pauli
The 9th International Countercurrent Chromatography Conference Held at Dominican University, Chicago, USA, August 1-3, 2016
Journal of Chromatography A, in press (2017)
dx.doi.org/xyz
PubMedCentral: PMC in progress

182
B Dietz, SN Chen, R Ramos Alvarenga, H Dong, D Nikolic, M Biendl, R van Breemen, J Bolton, G Pauli
DESIGNER Botanical Extracts as Tools to Balance Estrogenic and Chemopreventive Activities and Optimize Women’s Health
Journal of Natural Products 80, 2284-2294 (2017)
dx.doi.org/10.1021/acs.jnatprod.7b00284
PubMedCentral: PMC in progress

181
A Keiler, J Helle, M Bader, T Ehrhardt, K Nestler, G Kretzschmar, R Bernhardt, G Vollmer, D Nikolić, J Bolton, G Pauli, S -N Chen, B Dietz, R van Breemen, O Zierau
A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus
Phytomedicine 34, 50-58 (2017)
dx.doi.org/10.1016/j.phymed.2017.08.001
PubMedCentral: PMC in progress

180
J White, B O’Keefe, J Sharma, G Javed, V Nukala, A Ganguly, I Khan, N Kumar, H Mukhtar, G Pauli, L Walker, S Sivaram, P Rajaraman, T Trimble
India-U.S. Dialogue on Traditional Medicine - Towards Collaborative Research and Generation of an Evidence Base
Journal of Global Oncology, in press (2017)
dx.doi.org/10.1016/xxx
PubMedCentral: PMC in progress

179
A Jaja-Chimedza, B Graf, C Simmler, Y Kim, P Kuhn, G Pauli, I Raskin
Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract
PLOSone 12, e0182658 (2017)
doi.org/10.1371/journal.pone.0182658
PubMedCentral: PMC in progress

178
E Melchor-Martínez, D Silva-Mares, E Torres-López, N Waksman-Minsky, G Pauli, S-N Chen, M Niemitz, M Sánchez-Castellanos, A Toscano, G Cuevas, V Rivas-Galindo
Stereochemistry of a Second Riolozane and Other Diterpenoids from Jatropha dioica
Journal of Natural Products 80, 2252-2262 (2017)
dx.doi.org/10.1021/acs.jnatprod.7b00193
PubMedCentral: PMC in progress

177
C Simmler, D Lankin, D Nikolic, R van Breemen, G Pauli
Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A
Fitoterapia 121, 6-15 (2017)
dx.doi.org/10.1016/j.fitote.2017.06.017
PubMedCentral: PMC in progress

176
Y Liu, JB Friesen, E Grzelak, Q Fan, T Tang, K Duric, B Jaki, C Simmler, JB McAlpine, SG Franzblau, SN Chen, G Pauli
Sweet Spot Matching: a Thin-layer Chromatography-based Countercurrent Solvent System Selection Strategy
Journal of Chromatography A 1504, 46-54 (2017)
dx.doi.org/10.1016/j.chroma.2017.04.055
PubMedCentral: PMC in progress

175
D. Kulakowski, A. Leme-Kraus, J.-W. Nam, J. McAlpine, S.-N. Chen, G. Pauli, S. Ravindran, A. Bedran-Russo
Oligomeric proanthocyanidins released from dentin induce regenerative dental pulp cell response
Acta Biomaterialia 55, 262-270 (2017)
doi.org/10.1016/j.actbio.2017.03.051
PubMedCentral: PMC in progress

174
R. Phansalkar, C. Simmler, J. Bisson, S.-N. Chen, D. Lankin, J. McAlpine, M. Niemitz, G. Pauli
Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract
Journal of Natural Products 80, 634-647 (2017)
dx.doi.org/10.1021/acs.jnatprod.6b00923
PubMedCentral: PMC5368683 [Open Access Article]

173
A. Leme, B. Aydin, C. Vidal, R. Phansalkar, J.-W. Nam, J. McAlpine, G. Pauli, S.-N. Chen, A. Bedran-Russo
Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies
Journal of Dental Research 96, 406-412 (2017)
dx.doi.org/10.1177/0022034516680586
PubMedCentral: PMC in progress

172
K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
The Essential Medicinal Chemistry of Curcumin
Journal of Medicinal Chemistry 60, 1620-1637 (2017)
dx.doi.org/10.1021/acs.jmedchem.6b00975
PubMedCentral: PMC5346970 [Open Access Article]
altmetrics article statistics

172-Related Letter to the Editor
K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
Curcumin May (Not) Defy Science
ACS Medicinal Chemistry Letters, 8, 467-470
http://dx.doi.org/10.1021/acsmedchemlett.7b00139

171
J.W. Nam, R. Phansalkar, D.C. Lankin, J. McAlpine, A. Leme-Kraus, C. Vidal, A. Bedran-Russo, S.-N. Chen, G. Pauli
Absolute Stereochemistry of Native Oligomeric Proanthocyanidins with Dentin Biomodification Potency
Journal of Organic Chemistry 82, 1316-1329 (2017)
dx.doi.org/10.1021/acs.joc.6b02161
PubMedCentral: PMC in progress
[Featured in C&E News, March 2017: "Bark Extract Strengthens Bite "]

170
W. Gao, J. Napolitano, D. Lankin, J-.Y. Kim, Y.-Y. Jing, J.W. Soo, S.-N. Chen, G. Pauli
Computer-assisted 1H NMR Analysis of the anti-Tuberculosis Drug Lead Ecumicin
Magnetic Resonance in Chemistry 55, 239-244 (2017)
dx.doi.org/10.1002/mrc.4425
PubMedCentral: PMC5071145

169
G. Kim, A. Leme, B. Aydin, R. Phansalkar, J.W. Nam, G. Viana, C. Wu, S.-N. Chen, G. Pauli, A. Bedran-Russo
Effect of bioactive primers on bacterial-induced secondary caries at the tooth-resin interface
Operative Dentistry 42, 196-202 (2017)
dx.doi.org/10.2341/16-107-L
PubMedCentral: PMC in progress

2016top of list|by year ]

168
J. Bisson, C. Simmler, S.-N. Chen, J.B. Friesen, D. Lankin, J. McAlpine, G. Pauli
Dissemination of Original NMR Data Enhances Reproducibility and Integrity in Chemical Research
Natural Product Reports 33, 1028-1033 (2016)
dx.doi.org/10.1039/c6np00022c
PubMedCentral: PMC5001890

167
S. Wang, T. Dunlap, C. Howell, O. Mbachu, E. Rue, R. Phansalkar, S.-N. Chen, G. Pauli, B. Dietz, J. Bolton
Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation
Chemical Research in Toxicology 29, 1142-1150 (2016)
dx.doi.org/10.1021/acs.chemrestox.6b00112
PubMedCentral: PMC4951797

166
S. AbouZid, S.-N. Chen, J. McAlpine, J.B. Friesen, G. Pauli
Silybum marianum Pericarp Yields Enhanced Silymarin Products
Fitoterapia 122: 136-143 (2016)
dx.doi.org/10.1016/j.fitote.2016.04.012
PubMedCentral: PMC4939139

165
Y. Liu, J. Garzon, J.B. Friesen, Y. Zhang, J. McAlpine, D. Lankin, S.-N. Chen, G. Pauli
Countercurrent Assisted Quantitative Recovery of Metabolites from Plant-Associated Natural Deep Eutectic Solvents
Fitoterapia 122: 30-37 (2016)
dx.doi.org/10.1016/j.fitote.2016.04.019
PubMedCentral: PMC4968704

164
E. Grzelak, C.-H. Hwang, G. Cai, J.-W. Nam, M. Choules, W. Gao, D. Lankin, J. McAlpine, S. Mulugeta, J. Napolitano, J.-W. Suh, S. Yang, J. Cheng, H. Lee, J.-Y. Kim, S.-H. Cho, G. Pauli, S. Franzblau, B. Jaki
Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources
ACS Infectious Diseases 2: 294-301 (2016)
dx.doi.org/10.1021/acsinfecdis.5b00150
PubMedCentral: PMC4963014

163
Imai A, Lankin D, Nikolic D, Ahn S, van Breemen R, Chen SN, Farnsworth N, Pauli GF
Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa
Journal of Natural Products 79: 541-554 (2016)
dx.doi.org/10.1021/acs.jnatprod.5b00927
PubMedCentral: PMC4808447

162
Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF
Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
Journal of Medicinal Chemistry 59: 1671-1690 (2016)
dx.doi.org/10.1021/acs.jmedchem.5b01009
PubMedCentral: PMC4791574 [Open Access Article]

161
Pauli GF, Niemitz M, Bisson J, Lodewyk M, Soldi C, Shaw J, Tantillo D, Saya J, Vos K, Kleinnijenhuis R, Hiemstra H, Chen SN, McAlpine J, Lankin D, Friesen JB
Towards Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving
Journal of Organic Chemistry 81: 878-889 (2016)
dx.doi.org/10.1021/acs.joc.5b02456
PubMedCentral: PMC4746703 [Open Access Article]

160
Simmler C, Kulakowski D, Lankin D, McAlpine J, Chen SN, Pauli GF
Approaching a More Holistic Analysis of Complex Natural Products
Advances in Nutrition 7: 179-189 (2016)
dx.doi.org/10.3945/an.115.009928
PubMedCentral: PMC4717887

159
AbouZid S, Chen SN, Pauli GF
Silymarin content in Silybum marianum populations growing in Egypt
Industrial Crops and Products 83: 729-737 (2016)
dx.doi.org/10.1016/j.indcrop.2015.12
PubMedCentral: PMC4863705

2015top of list|by year ]

158
Liu Y, Friesen JB, Klein L, McAlpine J, Lankin D, Pauli GF, Chen SN
The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography
Journal of Chromatography A 1426: 248-251 (2015)
dx.doi.org/10.1016/j.chroma.2015.11.046
PubMedCentral: PMC4887286

157
Hajirahimkan A, Simmler C, Dong H, Lantvit D, Li G, Chen SN, Nikolic D, Pauli GF, van Breemen R, Bolton J
Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women’s health: differential effects of the Michael acceptors isoliquiritigenin and licochalcone A
Chemical Research in Toxicology 28: 2130-2141 (2015)
dx.doi.org/10.1021/acs.chemrestox.5b00310
PubMedCentral: PMC4898475

156
Liu Y, Friesen JB, McAlpine JB, Pauli GF
Solvent System Selection Strategies in Countercurrent Separation
Planta Medica 81: 1582-1591 (2015)
dx.doi.org/10.1055/s-0035-1546246
PubMedCentral: PMC4679665

155
Nikolic D, Lankin D, Cisowksa T, Chen S, Pauli GF, van Breemen R
Nitrogen-containing Constituents of Black Cohosh: Chemistry, Structure Elucidation and Biological Activities
Recent Advances in Phytochemistry 45: 31-75 (2015)
dx.doi.org/10.1007/978-3-319-20397-3
PubMedCentral: PMC3341503

154
Simmler C, Anderson J, Gauthier L, Lankin D, McAlpine J, Chen SN, Pauli GF
Metabolite Profiling and Classification of DNA Authenticated Licorice Botanicals
Journal of Natural Products 78: 2007-2022 (2015)
dx.doi.org/10.1021/acs.jnatprod.5b00342
PubMedCentral: PMC4553119

153
Nam JW, Phansalkar R, Lankin D, Bisson J, McAlpine J, Leme A, Vidal C, Ramirez B, Niemitz M, Bedran-Russo A, Chen SN, Pauli GF
Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency
Journal of Organic Chemistry 80: 7495-7507 (2015)
dx.doi.org/10.1021/acs.joc.5b01082
PubMedCentral: PMC4537297

152
Dunlap T, Wang S, Simmler C, Chen SN, Pauli GF, Dietz B, Bolton J
Differential effects of Glycyrrhiza species on genotoxic estrogen metabolism: licochalcone A downregulates P450 1B1 whereas isoliquiritigenin stimulates
Chemical Research in Toxicology 28: 1584-1594 (2015)
dx.doi.org/10.1021/acs.chemrestox.5b00157
PubMedCentral: PMC4664064

151
Pauli GF, Pro S, Chadwick L, Burdick T, Pro L, Friedl W, Novak, N, Maltby J, Qiu, F, Friesen JB
Real-Time Volumetric Phase Monitoring Advances Chemical Analysis by Countercurrent Separation
Analytical Chemistry 87:7418-7425 (2015)
dx.doi.org/10.1021/acs.analchem.5b01613
PubMedCentral: PMC4509944 [Open Access Article]

150
Friesen JB, McAlpine JB, Chen SN, Pauli GF
Countercurrent Separation of Natural Products: An Update
Journal of Natural Products 78: 1765-1796 (2015)
dx.doi.org/10.1021/np501065h
PubMedCentral: PMC4517501 [Open Access Article]

149
Part 26- Residual Complexity of Bioactive Natural Products
Napolitano J, Simmler C, Napolitano J, McAlpine J, Lankin D, SN Chen, Pauli GF
Digital NMR Profiles as Building Blocks: Assembling 1H Fingerprints of Steviol Glycosides
Journal of Natural Products 78: 658-665 (2015)
dx.doi.org/10.1021/np5008203
PubMedCentral: PMC4696868

148
Phansalkar R, Nam J-W, Chen, S-N, McAlpine, JB, Napolitano JF, Leme A, Vidal C, Aguiar T, Bedran Russo A, Pauli GF
A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential
Fitoterapia 101: 169-178 (2015)
dx.doi.org/10.1016/j.fitote.2014.12.006

PubMedCentral: PMC4346468

147
Friesen JB, Ahmed S, Pauli GF
Qualitative and Quantitative Evaluation of Solvent Systems for Countercurrent Separation
Journal of Chromatography A 1377: 55-63 (2015)
dx.doi.org/10.1016/j.chroma.2014.11.085
PubMedCentral: n/a

146
Gao W, Kim JY, Anderson J, Akopian T, Hong S, Jin JY, Kandror O, Kim JW, Lee IA, Lee SY, McAlpine JB, Mulugeta S, Sunoqrot S, Wang Y, Yang SH, Yoon TM, Goldberg A, Pauli GF, Suh JW, Franzblau SG, Cho SH
The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo
Antimicrobial Agents and Chemotherapy 58: 880-889 (2015)
dx.doi.org/10.1128/AAC.04054-14
[Open Access Article]
PubMedCentral: PMC4335914

2014top of list|by year ]

B-4 [Book Chapter]
Qiu F, McAlpine JB, Krause E, Chen SN, Pauli GF
Pharmacognosy of Black Cohosh: the Phytochemical and Biological Profile of a Major Botanical Dietary Supplement
In: Progress in the Chemistry of Organic Natural Products ("Zechmeister"), vol. 99, pp 1-68
Springer, Vienna/New York (2014)
Editors: Kinghorn AD, Falk H, Kobayashi J

145
Part 24 - Residual Complexity of Bioactive Natural Products
Ramos Alvarenga R, Friesen JB, Nikolic D, Simmler C, Napolitano J, van Breemen R, Lankin D, McAlpine J, Pauli GF, SN Chen
K-Targeted Metabolomic Profiling Extends Chemical Subtraction to DESIGNER Extracts: Selective Depletion of Extracts of Hops (Humulus lupulus)
Journal of Natural Products 77: 2595-2604 (2014)
dx.doi.org/10.1021/np500376g
PubMedCentral: PMC4280114

144
Vidal C, Leme A, Aguiar T, Phansalkar R, Nam JW, Bisson J, McAlpine J, Chen SN, Pauli GF, Bedran-Russo A
Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids
Langmuir 30: 14887-14893 (2014)
dx.doi.org/10.1021/la5034383

PubMedCentral: PMC4437200

143
Gao W, Kim JY, Chen SN, Cho S, Choi JK, Jaki B, Jin YY, Lankin D, Lee JE, Lee SY, McAlpine J, Napolitano J, Franzblau S, Suh JW, Pauli GF
Discovery and Characterization of the TB Drug Lead Ecumicin
Organic Letters 16: 6044-6047 (2014)
dx.doi.org/10.1021/ol5026603
PubMedCentral: n/a

142
Pauli GF, Chen SN, Simmler C, Lankin D, Goedecke T, Jaki B, Friesen JB, McAlpine J, Napolitano J
The Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
Journal of Medicinal Chemistry 57: 9220-9231 (2014)
dx.doi.org/10.1021/jm500734a
PubMedCentral: PMC4255677
ADDITIONAL INFO: Topic Page for this paper
PRACTICAL SUPPORT: Spreadsheet Calculations for qHNMR Analyses

141
Simmler C, Nikolic D, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quemener C, Audo G, Pauli GF
Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice
Journal of Natural Products 77: 1806-1816 (2014)
dx.doi.org/10.1021/np5001945
PubMedCentral: PMC4143180

140
Part 25 - Residual Complexity of Bioactive Natural Products
Pauli GF, Chen SN, Lankin D, Bisson J, Case R, Chadwick L, Goedecke T, Inui T, Krunic A, Jaki B, McAlpine J, Mo S, Napolitano J, Orjala J, Lehtivarjo J, Korhonen SP, Niemitz M
Essential Parameters for Spectral Analysis and Structural Dereplication by 1H NMR Spectroscopy
Journal of Natural Products 77: 1473-1487 (2014)
dx.doi.org/10.1021/np5002384
PubMedCentral: PMC4076039

139
Part 23 - Residual Complexity of Bioactive Natural Products
Riihinen K, Ou Z, Goedecke T, Lankin D, Pauli GF, Wu C
The Antibiofilm Activity of Lingonberry Flavonoids against Oral Pathogens is a Case Connected to Residual Complexity
Fitoterapia 97, 78-86 (2014)
dx.doi.org/10.1016/j.fitote.2014.05.012
PubMedCentral: n/a

138
Markus M, Luchsinger S, Yuk J, Ferrier J, Hicks J, Killday B, Berrue F, Kirby C, Knagge K, Goedecke T, Ramirez B, Lankin DC, Pauli GF, Burton I, Arnason J, Colson K
Distinguishing Vaccinium species by NMR-based chemical fingerprinting using spectra collected in different laboratories
Planta Medica 80: 732-739 (2014)
dx.doi.org/10.1055/s-0034-1368569
PubMedCentral: PMC4242896

137
van Breemen R, Yuan Y, Banuvar S, Shulman L, Qiu Z, Ramos Alvarenga R, Chen SN, Dietz B, Bolton B, Pauli GF, Krause E, Viana M, Nikolic D.
Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops
Molecular Nutrition and Food Research 58, 1962-1969 (2014)
dx.doi.org/10.1002/mnfr.201400245
PubMedCentral: PMC4265473

136
Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz B, Nikolic D,
Pauli GF, Bolton J, van Breemen R.
Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.
Biomedical Chromatography 28: 729-734 (2014)
dx.doi.org/10.1002/bmc.3177
PubMedCentral: PMC4240625

135
Schinkovitz A, Kaur A, Urban E, Zehl M, Pachnikova G, Wang Y, Kretschmer N, Slaninov I, Pauli GF, Franzblau S, Krupitza G, Bauer R, Kopp B
Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation
Journal of Natural Products 77: 1069-1073 (2014)
dx.doi.org/10.1021/np4008574

PubMedCentral: n/a

134
Vidal C, Aguiar T, Phansalkar R, McAlpine J, Napolitano J, Chen SN, Araujo L, Pauli GF, Bedran-Russo A
Galloyl Moieties Enhance the Dentin Biomodification Potential of Plant-derived Catechins
Acta Biomaterialia 10: 3288-3294 (2014)
dx.doi.org/10.1016/j.actbio.2014.03.036

PubMedCentral: PMC4041811

133
Part 22- Residual Complexity of Bioactive Natural Products
Qiu F, McAlpine J, Lankin D, Burton I, Karakach T, Chen SN,
Pauli GF
2D NMR Barcoding and Differential Analysis of Complex Mixtures for Chemical Identification: the Actaea Triterpenes
Analytical Chemistry 86: 3964-3972 (2014)
dx.doi.org/10.1021/ac500188j
PubMedCentral: PMC4004191
ADDITIONAL INFO: Topic Page for this paper

132
Ramos R, Wan B, Inui T, Franzblau S, Pauli GF, Jaki B
Airborne Anti-TB activity of Eucalyptus citriodora Essential Oil
Journal of Natural Products 77: 603-610 (2014)
dx.doi.org/10.1021/np400872m

PubMedCentral: n/a

131
Yuan Y, Qiu X, Nikolic D, Chen SN, Pauli GF, van Breemen R
Inhibition of Human Cytochrome P450 Enzymes by Hops (Humulus lupulus) and Hop Prenylphenols
European Journal of Pharmaceutical Sciences 53: 55-61 (2014)
dx.doi.org/10.1016/j.ejps.2013.12.003

PubMedCentral: PMC3987852

130
Aguiar T, Vidal C, Phansalkar R, Todorova I, Napolitano J, McAlpine J, Chen SN, Pauli G, Bedran-Russo A
Dentin Biomodification Depends on Polyphenol Source
Journal of Dental Research 93: 417-422 (2014)
dx.doi.org/10.1177/0022034514523783

PubMedCentral: PMC3957344

129
Liu Y, Chen SN, McAlpine JB, Klein LL, Friesen JB, Lankin DC,
Pauli G
Quantification of a Botanical Negative Marker without an Identical
Standard: Ginkgotoxin in Ginkgo biloba
Journal of Natural Products 77: 611-617 (2014)
dx.doi.org/10.1021/np400874z

PubMedCentral: n/a

128
Elkington B, Sydara K, Newsome A, Hwang CH, Simmler C, Lankin D, Napolitano J, Ree R, Graham J, Gyllenhaal C, Bouamanivong S, Souliy O, Pauli GF, Franzblau SG, Soejarto DD
New Finding Of An Anti-TB Compound In The Genus Marsypopetalum (Annonaceae) From A Traditional Herbal Remedy Of Laos
Journal of Ethnopharmacology 151: 903-911 (2014)
dx.doi.org/10.1016/j.jep.2013.11.057

PubMedCentral: PMC3933013

127
Bedran-Russo A, Pauli G, Chen SN, McAlpine J, Castellan C, Phansalkar R, Aguiar T, Vidal C, Napolitano J, Nam JW, Leme A
Dentin biomodification: Strategies, renewable resources and clinical applications
Journal of Dentistry 30: 62-76 (2014)
dx.doi.org/10.1016/j.dental.2013.10.012

PubMedCentral: PMC3972923

126
Simmler C, Napolitano JG, McAlpine JB, Chen SN, Pauli GF
Universal Quantitative Analysis of Complex Natural Samples
Current Opinion in Biotechnology 25: 51-59 (2014)
dx.doi.org/10.1016/j.copbio.2013.08.004

PubMedCentral: PMC3912461

125
Simmler C, Jones T, Anderson J, Nikolic D, van Breemen R, Soejarto D, Chen SN, Pauli GF
Species-specific Standardization of Licorice by Metabolomic Profiling of Flavanones and Chalcones
Phytochemical Analysis 26: 378-388 (2014)
dx.doi.org/10.1002/pca.2472

PubMedCentral: PMC4391967

124
Napolitano JG, Gödecke T, Lankin DC, Jaki BU, McAlpine JB, Chen SN, Pauli GF
Orthogonal Analytical Methods for Botanical Standardization: Determination of Green Tea Catechins by qNMR and LC-MS/MS
Journal of Pharmaceutical and Biomedical Analysis 93: 59-67(2014)
dx.doi.org/10.1016/j.jpba.2013.06.017
PubMedCentral: PMC3875626

123
Klein L, Wang Y, Jaki B, Lankin DC, Santarsiero B, Pauli GF, Franzblau SG
A Novel Indigoid Anti-tuberculosis Agent
Bioorganic Medicinal Chemistry Letters 24: 268-270 (2014)
dx.doi.org/10.1016/j.bmcl.2013.11.024

PubMedCentral: PMC3922930

2013top of list|by year]

122
Simmler C, Fronczek F, Pauli GF, Santarsiero B
Absolute Configuration of Naturally Occurring Glabridin
Acta Crystallographica Section C 69: 1212-1216 (2013)
dx.doi.org/10.1107/S0108270113018842
PubMedCentral
: PMC4028893

121
Cai G, Napolitano JG, McAlpine JB, Wang Y, Jaki, BU, Suh JW, Yang SH, Lee IA, Pauli G, Cho SH
Hytramycins V and I, Anti-Mycobacterium tuberculosis Hexapeptides from a Streptomyces hygroscopicus Strain
Journal of Natural Products 76: 2009-2018 (2013)
dx.doi.org/10.1021/np400145u

PubMedCentral: n/a

120
Hwang C, Jaki B, Klein L, Lankin DC, Napolitano J, Cho S, Franzblau SG, Stamets P, McAlpine JB, Pauli G
Anti-mycobacterial Coumarins from the Polypore Mushroom Fomitopsis officinalis
Journal of Natural Products 76: 1916-1922 (2013)
dx.doi.org/10.1021/np300603z
PubMedCentral
: PMC3851412

119
Napolitano JG, Lankin D, McAlpine JB, M. Niemitz, SP Korhonen, Chen SN, Pauli GF
Proton Fingerprints Portray Molecular Structures: Enhanced Description of the 1D 1H NMR Spectra of Small Molecules
Journal of Organic Chemistry 78: 9963-9968 (2013)
dx.doi.org/10.1021/jo4011624
PubMedCentral
: PMC3812940

118
Part 21- Residual Complexity of Bioactive Natural Products
Dong SH, Cai G, Napolitano JG, Nikolic N, Lankin DC, McAlpine JB, van Breemen R, Soejarto DD, Pauli GF, Chen SN
Lipidated Steroid Saponins from Dioscorea villosa
Fitoterapia 91: 113-124 (2013)
dx.doi.org/10.1016/j.fitote.2013.07.018

PubMedCentral: PMC3935402

117
Simmler C, Pauli GF, Chen SN
Phytochemistry and Biological Properties of Glabridin
Fitoterapia 90: 160-184 (2013)
dx.doi.org/10.1016/j.fitote.2013.07.003

PubMedCentral: PMC3795865

116
Rajihamikhan A, Simmler C, Anderson J, Yuan Y, Nikolic D, Chen SN, Dietz B, Pauli G, van Breemen R, Bolton J
Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms
Plos One 8: e67947 (2013)
dx.doi.org/10.1371/journal.pone.0067947

PubMedCentral: PMC3709979

115
Riihinen K, Velitchka M, Gödecke T, Soininen P, Laatikainen R, Veervort J, Lankin D,
Pauli GF
1H NMR Fingerprinting of Vaccinium vitis-idaea flavonoid glycosides
Phytochemical Analysis 24: 476-483 (2013)
dx.doi.org/10.1002/pca.2444

PubMedCentral: n/a

114
Part 20 - Residual Complexity of Bioactive Natural Products
Napolitano JG, Lankin D, Graf T, Friesen JB, Chen SN, McAlpine JB, Oberlies, NH, Pauli GF
HiFSA Fingerprinting Applied to Isomers with Near Identical NMR Spectra:
The Silybin/Isosilybin Case
Journal of Organic Chemistry 78: 2827-2839 (2013)
dx.doi.org/10.1021/jo302720h [Featured Article]

PubMedCentral: PMC3640553

113
Part 19 - Residual Complexity of Bioactive Natural Products
Gödecke T, Napolitano JG, Rodriguez Brasco MF, Chen SN, Jaki BU, Lankin D, Pauli GF
Validation of a Generic qHNMR Method for Natural Products Analysis
Phytochemical Analysis 24: 581-597 (2013)
dx.doi.org/10.1002/pca.2436
PubMedCentral
: PMC3990190

112
Dietz B, Hagos G, Eskra J, Wijewickrama G, Anderson J, Nikolic D, Guo J, Chen SN,
Pauli GF, van Breemen R, Bolton J
Differential Regulation of Detoxification Enzymes in Hepatic and Mammary Tissue by Hops (Humulus lupulus) in Vitro and in Vivo
Molecular Nutrition and Food Research 57: 1055–1066 (2013)
dx.doi.org/10.1002/mnfr.201200534

PubMedCentral: PMC2864769

111
Part 18 - Residual Complexity of Bioactive Natural Products
Simmler C, Hajirahimkhan A; Lankin DC, Bolton J, Jones T, Soejarto DD; Chen SN, Pauli GF
Dynamic Residual Complexity of the Isoliquiritigenin-Liquiritigenin Interconversion During
Bioassays
Journal of Agricultural and Food Chemistry 61: 2146-2157 (2013)
dx.doi.org/10.1021/jf304445p

PubMedCentral: PMC3728173

110
Cai G, Pauli GF, Wang Y, Jaki, BU, Franzblau SG
Rapid Determination of Growth Inhibition of Mycobacterium tuberculosis by GC-MS/MS Quantitation of Tuberculostearic Acid
Tuberculosis 93: 322-329 (2013)
dx.doi.org/10.1016/j.tube.2012.12.004

PubMedCentral: n/a

109
Part 17 - Residual Complexity of Bioactive Natural Products
Qiu F, Cai G, Jaki BU, Lankin DC, Franzblau SG, Pauli GF
Quantitative Purity-Activity Relationships of Natural Products: The Case of Anti-Tuberculosis Active Triterpenes from Oplopanax horridus
Journal of Natural Products 76: 413-419 (2013)
dx.doi.org/10.1021/np3007809

PubMedCentral: n/a

2012top of list|by year]

108
Part 16 - Residual Complexity of Bioactive Natural Products
Dong S, Nikolic D, Simmler C, Qiu F, van Breemen R, Soejarto D,
Pauli GF, Chen SN
Diarylheptanoids from Dioscorea villosa (Wild Yam)
Journal of Natural Products 75: 2168-2177 (2012)
dx.doi.org/10.1021/np300603z

PubMedCentral: PMC3710746

107
Petersen J, Plaikner M, Nasseri P, Rehder P, Koppelstätter C, Pauli GF, Glodny B
Influence of Renal Artery Variants, Number, Location, and Degree of Renal Artery Stenoses on the Atherosclerotic Burden of the Aorta
Journal of Investigative Medicine 60: 1033-1040 (2012)
dx.doi.org/10.231/JIM.0b013e3182650a29 [Publisher's link] [Ovid link]

PubMedCentral: n/a

106
Part 15 - Residual Complexity of Bioactive Natural Products
Inui T, Wang Y, Pro S, Franzblau SG, Pauli GF
Unbiased Evaluation of Bioactive Secondary Metabolites in Complex Matrices
Fitoterapia 83: 1218-1225 (2012)
dx.doi.org/10.1016/j.fitote.2012.06.012
PubMedCentral
: PMC3434706

105
Part 13 - Residual Complexity of Bioactive Natural Products
Napolitano J, Lankin D, Chen SN, Pauli GF
Complete 1H NMR Spectral Analysis of Ten Chemical Markers of Ginkgo biloba
Magnetic Resonances in Chemistry 50: 569-575 (2012)
dx.doi.org/10.1002/mrc.3829

PubMedCentral: PMC3590027

104
Part 12 - Residual Complexity of Bioactive Natural Products
Pauli GF, Chen SN, Friesen JB, McAlpine J, Jaki BU
Analysis and Purification of Bioactive Natural Products - The AnaPurNa Study
Journal of Natural Products, 75: 1243-1255 (2012)
dx.doi.org/10.1021/np300066q [Open Access Article]
PubMedCentral: PMC3381453

103
Part 14 - Residual Complexity of Bioactive Natural Products
Riihinen K, Gödecke T, Pauli GF
Purification of Berry Flavonoids by Long-bed Gel Permeation Chromatography
Journal of Chromatography A, 1244: 20-27 (2012)
dx.doi.org/10.1016/j.chroma.2012.04.060
PubMedCentral
: PMC3381453

102
Pauli GF, Gödecke T, Jaki BU, Lankin DC
Quantitative 1H NMR: development and potential of a method for natural products analysis - An Update
Journal of Natural Products 75: 834-851 (2012)
dx.doi.org/10.1021/np200993k
PubMedCentral: PMC3384681

101
Part 11 - Residual Complexity of Bioactive Natural Products
Qiu F, Friesen JB, McAlpine JB, Pauli GF
Design of Countercurrent Separation of Ginkgo biloba Terpene Lactones by Nuclear Magnetic Resonance
Journal of Chromatography A 1242: 26-34 (2012)
dx.doi.org/10.1016/j.chroma.2012.03.081
PubMedCentra
: PMC3388899

100
Part 10 - Residual Complexity of Bioactive Natural Products
Napolitano J, Gödecke T, Rodriguez Brasco MF, Jaki BU, Chen SN, Lankin DC, Pauli GF
The Tandem of Full Spin Analysis and qHNMR for the Quality Control of Botanicals Exemplified with Ginkgo biloba
Journal of Natural Products 75: 238-248 (2012)
dx.doi.org/10.1021/np200949v
PubMedCentra
: PMC3388902
ADDITIONAL INFO: Research Topic Page for this paper

99
Part 9 - Residual Complexity of Bioactive Natural Products
Qiu F, Imai A, McAlpine J, Lankin D, Burton I, Karakach T, Farnsworth N, Chen SN, Pauli GF
Dereplication, Residual Complexity and Rational Naming - the Case of the Actaea Triterpenes
Journal of Natural Products 75: 432-443 (2012)
dx.doi.org/10.1021/np200878s
PubMedCentral
: PMC3392135
ADDITIONAL INFO: Research Topic Page for this paper

98
Part 8 - Residual Complexity of Bioactive Natural Products
Goedecke T, Napolitano J, Yao P, Nikolic D, Dietz B, Bolton J, van Breemen R, Chen SN, Lankin D, Farnsworth N, Pauli GF
Integrated standardization concept for Angelica botanicals using quantitative NMR
Fitoterapia 83: 18-32 (2012)
dx.doi.org/10.1016/j.fitote.2011.08.017
PubMedCentral
: PMC3380541

97
Nikolic D, Goedecke T, Chen SN., White J, Lankin D, Pauli GF, van Breemen R
Mass Spectrometric Dereplication of Nitrogen-containing Constituents of Black Cohosh (Cimicifuga racemosa L.)
Fitoterapia 83: 441-460 (2012)
dx.doi.org/10.1016/j.fitote.2011.12.006
PubMedCentral
: PMC3341503

96
Madhubhani L, Hemachandra P, Chandrasena P, Esala R, Chen SN, Main M, Lankin D, Scism R, Dietz B, Pauli GF, Thatcher G, Bolton J
Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A)
Cancer Prevention Research 5: 73-81 (2012)
dx.doi.org/10.1158/1940-6207.CAPR-11-0348
PubMedCentral
: PMC3252489

B-3 [Book Chapter]
McAlpine JB, Friesen JB, Pauli GF
Separation of Natural Products by Countercurrent Chromatography
In: Natural Products Isolation
Springer, New York/Vienna (2012)

Editor: S. Sarker
dx.doi.org/10.1007/978-1-61779-624-1_9

2011top of list|by year]

95
Part 7 - Residual Complexity of Bioactive Natural Products
Molina-Salinas G, Rivas-Galindo V, Said-Fernández S, Lankin D, Muñoz M, Joseph-Nathan P, Pauli GF*, Waksman N* [*corresponding authors]
Stereochemical Analysis of Leubethanol, an Anti-TB Active Serrulatane, from Leucophyllum frutescens
Journal of Natural Products 74: 1842-1850 (2011)
dx.doi.org/10.1021/np2000667

94
Li J, Gödecke T, Chen SN, Imai A, Lankin D, Farnsworth N, Pauli GF , van Breemen R, Nikolic D
In vitro metabolic interactions between black cohosh (Cimicifuga racemosa L.) and tamoxifen via cytochrome P450 mediated pathways
Xenobiotica 41: 1021-1030 (2011)
dx.doi.org/10.3109/00498254.2011.603385

93
Choi Y, Jermihov K, Nam S, Sturdy M, Maloney K, Qiu X, Chadwick L, Main M, Chen SN, Farnsworth N, Pauli GF , Mesecar A, Fenical W, Pezzuto J, van Breemen R
Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS
Analytical Chemistry 83: 1048-1052 (2011)
dx.doi.org/10.1021/ac1028424

EDITORIAL
Pauli GF
Special Issue with Papers from the 2010 DSHEA Symposium, Chicago, IL (USA)
Fitoterapia 82: 1-4 (2011)
Link to Media Page with PODCAST about this SPECIAL ISSUE

92
Chen SN, Friesen JB, Nikolic D, Fong H, Webster D, van Breemen R, Farnsworth N, Pauli GF
Phytoconstituents of Vitex agnus-castus fruits
Fitoterapia 82: 528-533 (2011)
dx.doi.org/10.1016/j.fitote.2010.12.003

91
Webster D, Chen SN, Pauli GF, Farnsworth N, Wang ZJ
Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.
Biochemical Pharmacology 81: 170-177 (2011)
dx.doi.org/10.1016/j.bcp.2010.09.013

2010top of list|by year]

90
Aponte J, Vaisberg A, Castillo D, Gonzalez G, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman R, Bustamante J, Tarleton R, Wang Y, Franzblau S, Pauli GF, Sauvain M, Hammond G
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines
Bioorganic and Medicinal Chemistry 18: 2880-2886 (2010)
dx.doi.org/10.1016/j.bmc.2010.03.018

89
Inui T, Wang Y, Nikolic D, Smith D, Franzblau SG, Pauli GF
Sesquiterpenes from Oplopanax horridus
Journal of Natural Products 73: 663-567 (2010)
dx.doi.org/10.1021/np900674d

88
Castellan C, Pereira P, Viana G, Chen SN, Pauli GF, Bedran-Russo A
Solubility study of phytochemical cross-linking agents on dentin stiffness
Journal of Dentistry 38: 431-436 (2010)
dx.doi.org/10.1016/j.jdent.2010.02.002

87
Scher J, Schinkovitz A, Wang Y, Zapp J, Becker H, Franzblau SF, Pauli GF
Structure and Anti-TB Activity Trachylobane Diterpenes from the Liverwort Jungermannia exsertifolia ssp. cordifolia
Journal of Natural Products 73: 656-663 (2010)
dx.doi.org/10.1021/np900806j

86
Part 6 - Residual Complexity of Bioactive Natural Products
Pauli GF, Friesen B, Goedecke T, Farnsworth N, Glodny B
Occurrence of Progesterone and Related Animal Steroids in Two Higher Plants
Journal of Natural Products 73: 338-345 (2010)
dx.doi.org/10.1021/np9007415
[Featured in C&E News, Feb 2010: "Progesterone Proof"]

85
van Breemen R, Liang W, Banuvar S, Shulman L, Pang Y, Tao Y, Nikolic S, Krause E, Fabricant D, Chen S.-N., Hedayat S, Bolton J, Pauli GF, Piersen C, Krause E, Geller S, Farnsworth N
Pharmacokinetics of 23-epi-26-deoxyactein in women following oral administration of a standardized extract of Cimicifuga racemosa L. (Nutt.) (black cohosh)
Clinical Pharmacology and Therapeutics 87: 219-25 (2010)
dx.doi.org/10.1038/clpt.2009.251

2009top of list|by year]

84
Geller S, Shulman L, van Breemen R, Banuvar S, Epstein G, Hedayat S, Nikolic S, Krause E, Piersen C, Bolton J, Pauli GF, Farnsworth N
Safety and Efficacy of Black Cohosh and Red Clover for the Management of Vasomotor Symptoms
Menopause 16: 1156-66 (2009)
dx.doi.org/10.1097/gme.0b013e3181ace49b

83
Friesen JB, Pauli GF
Binary concepts and standardization in counter-current separation technology.
Journal of Chromatography A 1116: 4237-44
(2009)
dx.doi.org/10.1016/j.chroma.2009.01.048

82
Gödecke T, Lankin DC, Nikolic D, Chen SN, van Breemen RB, Farnsworth NR, Pauli GF
Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa).
Journal of Natural Products 72: 433-437
(2009)
dx.doi.org/10.1021/np800144q

81
Part 5 - Residual Complexity of Bioactive Natural Products
Chen SN, Lankin D, Chadwick L, Jaki B, Pauli GF
Dynamic Residual Complexity of Natural Products by qHNMR: Solution Stability of Desmethylxanthohumol
Planta Medica 75: 757-762 (2009)
dx.doi.org/10.1055/s-0028-1112209

80
Friesen JB, Pauli GF
GUESSmix-guided optimization of elution–extrusion counter-current separations.
Journal of Chromatography A 1216: 4225-4231
(2009)
dx.doi.org/10.1016/j.chroma.2008.12.053

79
Part 4 - Residual Complexity of Bioactive Natural Products
Gödecke T, Chen SN, Lankin D, Nikolic D, van Breemen R, Pauli GF
Phytochemistry of Cimicifugic Acids and Associated Bases in Cimicifuga racemosa Root Extracts
Phytochemical Analysis 20: 120-131 (2009)
dx.doi.org/10.1002/pca.1106

2008top of list|by year]

78
Powell S, Goedecke T, Nikolic D, Chen S, Lankin D, Dietz B, Farnsworth N, von Breemen R, Pauli GF, Bolton J
Analysis of the In Vitro Serotonergic Activity of Black Cohosh and Identification of N(omega)-methylserotonin as Bioactive Constituent
Journal of Agricultural and Food Chemistry 56: 11718-11726 (2008)
dx.doi.org/10.1021/jf803298z

77
Part 1 - Residual Complexity of Bioactive Natural Products
Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang F, Wang Y, Pauli GF
Purity Bioactivity Relationships – The Case of Anti-TB Active Ursolic Acid
Journal of Natural Products 71: 1742-1748 (2008)
dx.doi.org/10.1021/np800329j

76
Pauli GF, Pro S, Friesen B
Countercurrent Separation of Natural Products
Journal of Natural Products 71: 1489-1508 (2008)
dx.doi.org/10.1021/np800144q

75
Yuan H, He R, Wan B, Wang Y, Pauli GF, Franzblau SG, Kozikowski A
Modification of the Side Chain of the Natural Product Micromolide, an Anti-tuberculosis Agent
Bioorganic & Medicinal Chemistry Letters 18: 5311-5315 (2008)
dx.doi.org/10.1016/j.bmcl.2008.08.027

74
Part 3 - Residual Complexity of Bioactive Natural Products
Schinkovitz A, Pro S, Main M, Chen SN, Jaki BU, Lankin DC, Pauli GF
The Dynamic Nature of the Ligustilide Complex
Journal of Natural Products 71: 1606-1611 (2008)
dx.doi.org/10.1021/np800137n

73
Dietz B, Liu D, Hagos G, Schinkovitz A, Pro S, Deng S, Yao P, Farnsworth N,
Pauli GF, van Breemen R, Bolton J
Angelica sinensis and Its Alkylphthalides Induce the Detoxification Enzyme NAD(P)H:quinone Oxidoreductase 1 by Alkylating KEAP1
Chemical Research in Toxicology 21: 1939-1948 (2008)
dx.doi.org/10.1021/tx8001274

72
Overk C, Guo J, Chadwick L, Main M, Lantvit D, Minassi A, Appendino G, Pauli GF, van Breemen R, Farnsworth N, Bolton J
In Vivo Estrogenic Comparisons of Trifolium pratense (Red Clover), Humulus lupulus (Hops), and the Pure Compounds Isoxanthohumol and 8-Prenylnaringenin
Chemico-Biological Interactions, 176, 30-39 (2008)
dx.doi.org/10.1016/j.cbi.2008.06.005

71
Part 2 - Residual Complexity of Bioactive Natural Products
Chen S, Turner A, Jaki B, Nikolic D, van Breemen R, Friesen B, Pauli GF
An Experimental Implementation of Chemical Subtraction
Journal of Pharmaceutical and Biomedical Analysis 46: 692-698 (2008)
dx.doi.org/10.1016/j.jpba.2007.12.014

70
Friesen B & Pauli GF
Performance Characteristics of Countercurrent Separation in Natural Product Analysis
Journal of Agricultural & Food Chemistry 56: 19-28 (2008)
dx.doi.org/10.1021/jf072415a

69
Overk C, Yao P, Chen SN, Imai A, Main M, Schinkovitz A, Pauli GF, Bolton J
High-Content Screening and Mechanism-Based Evaluation of Estrogenic Botanical Extracts
Combinatorial Chemistry and High-throughput Screening 11: 283-293 (2008)
dx.doi.org/10.2174/138620708784246022

68
Farnsworth N, Krause E, Bolton J, Pauli GF, van Breemen R, Graham J
UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use
American Journal of Clinical Nutrition 87: 504S-508S (2008)
[No DOI; journal link]

67
Deng S, Wang Y, Inui T, Chen SN, Farnsworth N, Cho S, Franzblau S, Pauli GF
Anti-TB Polyynes from the Roots of Angelica sinensis
Phytotherapy Research 22: 878-882 (2008)
dx.doi.org/10.1002/ptr.2303

B-2 [Book Chapter]
Pauli GF, Jaki BU, Lankin DC, Burton I, Walter J
Quantitative NMR (qNMR) of Bioactive Natural Products
In: Bioactive Natural Products: Detection, Isolation and Structure Determination
2nd Edition, CRC Press, Boca Raton, FL (2008)

Editors: S. Colegate & R. Molyneux

2007top of list|by year]

66
Pang Y, Nikolic D, Zhu D, Chadwick L, Farnsworth N, Pauli GF, van Breemen R
Binding of the Hop (Humulus lupulus L.) Chalcone Xanthohumol to Cytosolic Proteins in Caco-2 Intestinal Epithelial Cells.
Molecular Nutrition & Food Research 51: 872-879 (2007)
dx.doi.org/10.1002/mnfr.200600252

65
Niemitz M, Laitikainen R, Chen SN, Kleps R, Kozikowski A, Pauli GF
Complete 1H NMR Spectral Fingerprint of Huperzine A
Magnetic Resonance in Chemistry 45: 878-882 (2007)
dx.doi.org/10.1002/mrc.2061

64
Chen SN, Lankin DC, Nikolic D, Fabricant D, Lu ZZ, Ramirez B, van Breemen R, Fong HHS, Farnsworth NR, Pauli GF
Chlorination Diversifies Cimicifuga racemosa Triterpene Glycosides
Journal of Natural Products 70: 1016-1023 (2007)
dx.doi.org/10.1021/np0700319

63
Berthod A, Friesen JB, Inui T, Pauli, GF
Elution-Extrusion Countercurrent Chromatography: Theory and Concepts in Metabolic Analysis.
Analytical Chemistry 79: 3371-3382 (2007)
dx.doi.org/10.1021/ac062397g
Featured article in May 2007, “Research Profile: Revisiting liquid stationary phases"

62
Inui T, Wang Y, Smith D, Franzblau S, Pauli GF
Counter-Current Chromatography-Based Analysis of Synergy in an Anti-tuberculosis Ethnobotanical.
Journal of Chromatography A 1151: 211-215 (2007)
dx.doi.org/10.1016/j.chroma.2007.01.127

61
Friesen JB & Pauli GF
Reciprocal Symmetry Plots as a Representation of Countercurrent Chromatograms.
Analytical Chemistry 79: 2320-2324 (2007)
dx.doi.org/10.1021/ac062007q

60
Friesen JB, Pauli GF
Rational Development of Solvent System Families in Counter-current Chromatography.
Journal of Chromatography A 1151: 51-59
(2007)
dx.doi.org/10.1016/j.chroma.2007.01.126

59
Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG
Low Oxygen Recovery Assay (LORA) to rapidly screen for compounds
active against non-replicating Mycobacterium tuberculosis.
Antimicrobial Agents and Chemotherapy 51: 1380-1385 (2007)
dx.doi.org/10.1128/AAC.00055-06

58
Case R, Wang Y, Franzblau SG, Matainaho L, Piskaut P, Soejarto D, Pauli GF
Advanced Applications of CCC in the isolation of anti-TB constituents from
Dracaena angustifolia.
Journal of Chromatography A 1151: 169-174 (2007)
dx.doi.org/10.1016/j.chroma.2007.01.022

57
Pauli GF, Jaki BU, Lankin DC
A routine experimental protocol for qHNMR illustrated with taxol
Journal of Natural Products 70: 589-595 (2007)
dx.doi.org/10.1021/np060535r

56
Berthod A, Conway W, Ito Y, Pauli GF, Sutherland I
CCC 2006 - The Fourth International Conference on Countercurrent Chromatography
in Bethesda (MD): Natural Products and Scale-up Applications
Journal of Chromatography A 1151: 1-5 (2007)
dx.doi.org/10.1016/j.chroma.2006.10.069

55
Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF
Coumaroyl Iridoids and a Depside from Cranberry (Vaccinium macrocarpon)
Journal of Natural Products 70: 253-258 (2007)
dx.doi.org/10.1021/np060260f

2006top of list|by year]

54
Glodny B & Pauli GF
The vasodepressor function of the kidney: further characterization of
medullipin and a second hormone designated angiolysin
Hypertension Research 29: 533-544 (2006)
dx.doi.org/10.1291/hypres.28.827

53
Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Fong HHS,
Farnsworth NR, Pauli GF
GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels
Phytochemical Analysis 17, 398-405 (2006)
dx.doi.org/10.1002/pca.937

52
Guo J, Nikolic D, Chadwick L, Pauli GF, van Breemen R
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.)
Drug Metabolism and Disposition 34: 1152-1159 (2006)
dx.doi.org/10.1124/dmd.105.008250

51
Glodny B & Pauli GF
Preparation of a vasodepressor kidney medulla extract devoid of vasodepressor Prostaglandins
Acta Physiologica 187: 419-430 (2006)
dx.doi.org/10.1124/dmd.105.008250
Editor’s choice article in July 2006, subtitled “Medullipin rises like Phoenix form the ashes?"

50
He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, Zheng Q
Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of clack cohosh products
Journal of Chromatography A 1112: 241-254 (2006)
http://dx.doi.org/10.1016/j.chroma.2006.01.004

49
Deng S, Chen SN, Yao P, Nikolic D, van Breemen R, Bolton J, Fong H, Farnsworth NR, Pauli GF
Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis
Journal of Natural Products 69: 536-541 (2006)
dx.doi.org/10.1021/np050301s

48
Booth N, Chen SN, Overk C, Yao P, Bolton J, Pauli GF, Farnsworth NR
Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones
Journal of Agricultural and Food Chemistry 54: 1277-1282 (2006)
dx.doi.org/10.1021/jf052927u

47
Booth N, Overk C, Yao P, Burdette J, Nikolic D, Chen SN, Bolton J, van Breemen R,
Pauli GF, Farnsworth N
The chemical and biological profile of a red clover (Trifolium pratense) phase II clinical extract
Journal of Alternative and Complimentary Medicine 12: 133-139 (2006)
dx.doi.org/10.1089/acm.2006.12.133

46
Case R, Franzblau SG, Wang Y, Cho S, Soejarto D, Pauli GF
Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus
Journal of Ethnopharmacology 106: 82-89 (2006)
dx.doi.org/10.1016/j.jep.2005.12.005

45
Chadwick L, Farnsworth NR, Pauli GF
The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on their estrogenic properties
Phytomedicine 13: 119-131 (2006)
http://dx.doi.org/10.1016/j.phymed.2004.07.006
Among the Top-25 of the most-accessed Phytomedicine articles

44
Jaki BU, Franzblau SG, Cho SH, Pauli GF
Development of an extraction method for mycobacterial metabolome analysis
Journal of Pharmaceutical and Biomedical Analysis 41: 196-200 (2006)
dx.doi.org/10.1016/j.jpba.2005.10.022

B-1 [Book Chapter]
Fong HHS , Farnsworth NR, Pauli GF, Bolton J, van Breemen R, Banuvar S
Evidence based herbal medicine: Challenges in efficacy and safety assessment
In: Current Review of Chinese Medicine. Quality Control of Herbs and Herbal Materials; Leung, P.-C., Fong, H. Xue, C. (editors) Vol 2, 11-26 (2006)

2005top of list|by year]

43
Case R, Pauli GF, Soejarto D
Factors in maintaining indigenous knowledge among ethnic communities of Manus Island, Economic Botany 59: 356-365 (2005)
[NoDOI, link to journal]

42
Glodny B & Pauli GF
Medullopressin, a new short-acting pressor activity from the renal medulla.
Hypertension Research 28: 827-836 (2005)
dx.doi.org/10.1291/hypres.28.827

41
Turner A; Chen SN, Joike M, Pendland S, Pauli GF, Farnsworth NR. 2005.
A new adherence assay: Inhibition of uropathogenic E. coli by cranberry juice,
Journal of Agricultural and Food Chemistry 53: 8940-8947 (2005)
dx.doi.org/10.1021/jf052035u

40
Fabricant D, Nikolic D, Chen SN, Jaki B, Krunic A, Lankin D, van Breemen R, Farnsworth NR, Pauli GF
Cimipronidine: A cyclic guanidine alkaloid from Cimicifuga racemosa (L.) Nutt.
Journal of Natural Products 68: 1266-1270 (2005)
dx.doi.org/10.1021/np050066d

39
Pauli GF, Case R, Inui T, Wang Y, Cho S, Fischer N, Franzblau S.
New perspectives on natural products in TB drug research
Life Sciences 78: 485-494 (2005)
dx.doi.org/10.1016/j.lfs.2005.09.004

38
Overk C, Yao P, Chadwick L, Cuendet M, Fong HHS, Pauli GF, Farnsworth NR, Bolton J
Comparison of the in vitro estrogenic activities of purified compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)
Journal of Agricultural and Food Chemistry 53: 6246-6253 (2005)
dx.doi.org/10.1021/jf050448p

37
Dietz B, Kang YH, Liu G, Eggler A, Yao P, Chadwick L, Pauli GF, Farnsworth NR, Mesecar A, van Breemen R, Bolton J
Xanthohumol Isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase
Chemical Research in Toxicology 18: 1296-1305 (2005)
dx.doi.org10.1021/tx050058x
[Among the Top-20 of the most-accessed CRT articles in III/2005]

36
Friesen B & Pauli GF
G.U.E.S.S. to make Generally Useful Estimations of Solvent Systems in CCC.
Journal of Liquid Chromatography & Relat. Technologies 28: 2777-2806 (2005)
dx.doi.org/10.1080/10826070500225234

35
Dietz B, Fey S, Pauli GF, Farnsworth NR, Mahady G
Valerian extract and valerenic acid are partial agonists of the 5HT5A-receptor in vitro
Molecular Brain Research 138: 191-197 (2005)
dx.doi.org/10.1016/j.molbrainres.2005.04.009

34
Inui T, Case R, Chou E, Soejarto D, Fong HHS, Franzblau S, Smith D, Pauli GF. 2005.
Anti-TB ethnobotanicals and plants from Alaska and Asia - The potential of CCC
Journal of Liquid Chromatography and Related Technologies 28: 2017-2028 (2005)
dx.doi.org/10.1081/JLC-200063660

33
Chadwick L, Fong HHS, Farnsworth NR, Pauli GF
CCC sample cutting for isolation of prenylated phenolics from hops
Journal of Liquid Chromatography and Related Technologies 28: 1959-1969 (2005)
dx.doi.org/10.1081/JLC-200063634

32
Seigler D, Pauli GF, Fröhlich R, Wegelius E, Nahrstedt A, Glander K, Ebinger J
Cyanogenic clycosides and menisdaurin from Guazuma ulmifolia, Ostrya virginiana, Tiquilia plicata, and Tiquilia canescens
Phytochemistry 66: 1567-1580 (2005)
dx.doi.org/10.1016/j.phytochem.2005.02.021

31
Conway W, Chadwick L, Fong HHS, Farnsworth N, Pauli GF
Extra-Column dead volume in countercurrent chromatography
Journal of Liquid Chromatography and Related Technologies 28: 1799-1818 (2005)
dx.doi.org/10.1081/JLC-200063448

30
Nikolic D, Li Y, Chadwick L, Pauli GF, van Breemen R
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids form hops, in human liver microsomes
Journal of Mass Spectrometry 40: 289-299 (2005)
dx.doi.org/10.1002/jms.753

29
Ma C, Case C, Wang Y, Zhang H, Tan G, Van Hung N, Cuong N, Franzblau S, Soejarto D, Fong H, Pauli GF
Anti-tuberculosis compounds from Micromelum hirsutum
Planta Medica 71: 261-267 (2005)
dx.doi.org/10.1055/s-2005-837826

28
Pauli GF, Jaki B, Lankin D
Quantitative 1H NMR: Development and potential of a method for natural products Analysis
Journal of Natural Products 68: 133-149 (2005)
dx.doi.org/10.1021/np0497301
JNP/ACS Highly Cited Paper, ranking in the top 1% of the most-cited papers during the last 10 years [12/2010]

27
Chen SN, Fabricant D, Pauli GF, Fong HHS, Farnsworth NR. 2005. Synthesis of Cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa
Natural Products Research 19: 287-290 (2005)
dx.doi.org/10.1016/S0031-9422(02)00209-1

26
Chadwick L, Fröhlich R, Chen S, Bolton J, van Breemen R, Overk C, Burdette J, Nikolic D, Fong H, Farnsworth N, Pauli GF
Estrogens and congeners from hops (Humulus lupulus).
Journal of Natural Products 67: 2024-2032 (2004)
dx.doi.org/10.1021/np049783i

2004-2000top of list|by year]

25
Jaki B, Franzblau S, Pauli GF
An NMR method towards routine chiral determination of natural products
Phytochemical Analysis 15: 213-219 (2004)
dx.doi.org/10.1002/pca.760

24
Seigler DS, Pauli GF, Nahrstedt A, Leen R
Cyanogenic allosides and glucosides from Passiflora edulis and Carica papaya
Phytochemistry 60: 873-882 (2003)
dx.doi.org/10.1016/S0031-9422(02)00170-X

23
Jaki B, Sticher O, Veit M, Fröhlich R, Pauli GF
Evaluation of glucoiberin reference material from Iberis amara by
spectroscopic fingerprinting
Journal of Natural Products 65: 517-522 (2002)
dx.doi.org/10.1021/np0100800

22
Glodny B, Pauli GF, Kühle C, Spiegel H, Winde G, Vetter H
Blood Pressure-lowering Function of the Renal Medulla
Nieren- und Hochdruckkrankheiten 30: 228-231 (2001)
[No DOI available]

21
Pauli GF
qNMR - A versatile concept for the validation of natural product reference compounds
Phytochemical Analysis 12: 28-42 (2001)
dx.doi.org/10.1002/pca.760

20
Herwig R., Glodny B., Pauli GF
Prognoses of Malignancy in Cases of Pheochromocytomas?
Urology 56: 891 (2000)
[No DOI available]

19
Fröhlich R & Pauli GF
alpha-Onocerin
Acta Crystallographica C 56: 1476-1477 (2000)
dx.doi.org/10.1107/S0108270100012403

18
Pauli GF
Comprehensive Spectroscopic Investigation of alpha–Onocerin
Planta Medica
66: 299-302 (2000)
dx.doi.org/10.1055/s-0029-1243138

17
Pauli GF
Higher order and substituent chemical shift effects in the proton NMR of glycosides
Journal of Natural Products 63: 834-838 (2000)
dx.doi.org/10.1021/np990527t

16
Pauli GF
& Fröhlich R
Chiral Key Positions in Uzara Steroids
Phytochemical Analysis 11: 79-89 (2000)
dx.doi.org/10.1002/(SICI)1099-1565(200003/04)11:2<79::AID-PCA492>3.0.CO;2-H

1999-1990top of list|by year]

15
Pauli GF, Matthiesen U, Fronczek F
Sulfates as Novel Steroid Metabolites in Higher Plants
Phytochemistry 52: 1075-1084 (1999)
dx.doi.org/10.1016/S0031-9422(99)00393-3

14
Pauli GF, Kuczkowiak U, Nahrstedt A
Solvent Effects in the Dereplication of Caffeoyl Quinic Acid Derivatives
Magnetic Resonance in Chemistry 37: 827-836 (1999)
dx.doi.org/10.1002/(SICI)1097-458X(199911)37:11<827::AID-MRC568>3.0.CO;2-W

13
Veit M, Pauli GF
Major Flavonoids from Arabidopsis thaliana L. leaves
Journal of Natural Products 62: 1301-1303 (1999)
dx.doi.org/10.1021/np990080o

12
Çalis I, Akbay P, Kuruüzüm A, Yalçin F, Sahin P, Pauli GF
Phenylethanoid and Cardioactive Glycosides from Digitalis ferruginea
Pharmazie 54: 926–930 (1999)
dx.doi.org/10.1002/chin.200010190

11
Kruse SO, Löhning A, Pauli GF, Winterhoff H, Nahrstedt A
Fukiic and Piscidic Acid Esters from the Rhizome of Cimicifuga racemosa and the Estrogenic Activity of Fukinolic Acid
Planta Medica 65: 763-764 (1999)
dx.doi.org/10.1055/s-2006-960862

10
Weltring K, Wessels J, Pauli GF
Metabolism of the Tomato Saponin alpha–Tomatine by Gibberella pulicaris
Phytochemistry 48: 1321-1328 (1998)
dx.doi.org/10.1016/S0031-9422(97)00847-9

9
Pauli GF, Poetsch F, Nahrstedt A
Structure Assignment of Natural Quinic Acid Derivatives Using Proton Nuclear Magnetic Resonance Techniques
Phytochemical Analysis 9: 177-185 (1998)
dx.doi.org/10.1002/(SICI)1099-1565(199807/08)9:4<177::AID-PCA404>3.0.CO;2-3

8
Pauli G, Naumann M, Fischer N
Application of Soft Pulse 1D NMR: Sweroside from a Potential Native American Anti-TB Drug
Spectroscopy Letters 23: 903-913 (1995)
http://dx.doi.org/10.1080/00387019508009929

7
Pauli GF
The Cardenolides of Speirantha convallarioides
Planta Medica 61: 162-166 (1995)
dx.doi.org/10.1055/s-2006-958039

6
Pauli GF
Adoligoses, Oligosaccharides of Rare Sugars from Adonis aleppica
Journal of Natural Products 58: 483-495 (1995)
dx.doi.org/10.1021/np50118a002

5
Pauli GF, Junior P
Phenolic Glycosides from Adonis aleppica
Phytochemistry 38: 1245-1250 (1995)
dx.doi.org/10.1016/0031-9422(94)00635-7

4
Pauli GF, Ofterdinger S, Teborg D
Digitalis, Scrophularia & Co.
Deutsche Apotheker Zeitung 135: 111-132 (1995)
[No DOI available]

3
Pauli GF, Berger S, Matthiesen U, Junior P
Alepposides, Cardenolide Oligoglycosides from Adonis aleppica
Journal of Natural Products 56: 67-75 (1993)
dx.doi.org/10.1021/np50091a010

2
Pauli GF, Junior P, Matthiesen U
Aleppotrioloside, an Aliphatic Alcohol Glycoside from Adonis aleppica
Phytochemistry 31: 2522-24 (1992)
dx.doi.org/10.1016/0031-9422(92)83314-O

1
Pauli GF, Junior P
On the track of Adonis aleppica
Deutsche Apotheker Zeitung 130: 2170-74 (1990)
[No DOI available]

DOI Links: DOI links and/or links to their online abstracts and full-text versions are provided. For comprehensive coverage or to interface with bibliographic software, please query the NLM Medline database with the author term "pauli gf", search SciFinder with the author term "pauli guido f", or consult the BioInfoBank Library.
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Publications by Year
2017
, 2016
, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004-2000, 1999-1990

Research Topics
- Residual Complexity [Publication Series]
- HiFSA in NMR

Publication Resources

Featured Open Access Raw NMR Data Sharing and use of QuILTS

Pauli GF et al. Towards Structural Correctness: Aquatolide and the Importance of 1D Proton NMR FID Archiving
Journal of Organic Chemistry 81: 878-889 (2016)

 

IMPS Part II:
The Essential Medicinal Chemistry of Curcumin

K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
The Essential Medicinal Chemistry of Curcumin
Journal of Medicinal Chemistry 60, 1620 (2017)
LTTE:
ACS Medicinal Chemsitry Letters, 8, 467-470

Open Access Article Altmertics Statistics
Report in Nature
ACS Editorial in PAINS and IMPS

Raw Data Initiative in
 

Raw NMR Data Enhances Integrtiy and Reproducibility

Bisson J et al. Dissemination of Original NMR Data Enhances Reproducibility and Integrity in Chemical Research
Natural Product Reports 33: 1028-1033 (2016)

 

IMPS Part I :
How IMPs can undermine Natural Product-Based Drug Discovery

Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF. Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
J. Med. Chem. 59: 1671-90 (2016) ResComplx Ser#28

 

PUBLICATION SERIES

Residual Complexity of Bioactive Natural Products is a series dealing with the subtle but significant convolution of major and minor chemical species in natural products and other biochemical reaction mixtures.

Botanical Integrity Column is a series in Herbal Gram dedicated to a multi-layer model of evidence for reproducibility in basic and clinical botanical research

 
 
ADDITIONAL INFO
Research Topic Pages with Extended Information on the subject of the publication, such as additional data, comments and useful experimental information.

Phytochemistry and DNA Analysis of Licorice/Glycyrrhiza

Article on the Methodology and Importance of Disinguishing the three most used Glycyrrhiza Species
J. Nat. Prod. 78, 2007 (2015)

 
MANUSCRIPTING
Manuscript Writing Support Pages
offer downlaod of DOC templates and Endnote ENS style files for journals we publish in.
 
 

Purity Evaluation by Quantitative 1H NMR
Perspectives Article on the Importance and Potential of qHNMR in Medicinal and Natural Products Chemistry
J. Med. Chem. 57 (2014)
see also:
J. Med. Chem. Editorial on qHNMR for Purity Analysis in Medicinal Chemistry

 
   

 
 

qNMR.org

 
   

countercurrent.org

   

Ecumicin - A New Anti-TB Drug Lead
See reports in
- Antimicrobial Agents and Chemotherapy 58, 880 (2015)
- Organic Letters 16, 6044 (2014)
- Magnetic Resonance in Chemistry 55, (2017)

 
 

Black Cohosh Review Comprehensive Chapter in vol. 99 of the Zechmeister Book Series "Progress in the Chemistry of Organic Natural Products"

 
 

 

 
droplet countercurrent chromatography      
       
     
       

 

     
       

Purity by qNMR Comprehensive Description of qNMR Purity Assays and why they are important in the Journal of Medicinal Chemistry 57, 9220 (2014)

     
     
       
     
       
     
       
     
       
     
       
     
       
     
       

Purity by qNMR Comprehensive Description of qNMR Purity Assays and why they are important in the Journal of Medicinal Chemistry

 
     
       
     
       
       
       
       
       
       
       
       
       
       
       
       
       
       
 
       
       
 
       
       
       
 
 
       
       
       
       
       
       
       
       
       
 
 
     
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