Countercurrent Chromatography Portal

Countercurrent Chromatography (CCC) and Countercurrent Separation (CS)

Named after Craig's renowned countercurrent distribution (CCD), chromatographic liquid-liquid separation techniques are commonly referred to as countercurrent or partition chromatography (CCC, CPC). Owing to the fact that routine experimental setups such as HSCCC and CPC do not use true countercurrent flow of liquids, partition chromatography is the more generic term and actually describes the underlying principle of partitioning the analytes between two immiscible liquid phases. This also illustrates the particular power of CCC/CPC.

  • As only solvents are involved and solid supports avoided, irreversible adsorption cannot occur, sample degradation is minimized, and a theoretical 100% sample recovery is achievable.

  • The partition coefficient, K, is an important physicochemical constant of each molecular species, which can be used to target its analysis

Countercurrent Research at UIC Chicago

Our natural products group at UIC has an extensive track record and expertise in applying and developing CCC experimental techniques.

Countercurrent Chromatography: Background

Countercurrent Chromatography: Resources

Droplets in DCCC

UPCOMING International CCC Conference
CCC 2022 Online August 1+2, 2022

International CCC Conference
CCC 2016

August 1-3, 2016
Dominican Univ. River Forest, IL

K Power = Targeting Compounds by their K Values: Ginkgotoxin Analysis by CS without identical reference standards

Visit the CCC Information Portal

TLP is currently being migrated. Pleas stay tuned.

Coils and Step Gradients
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