Countercurrent Chromatography Portal

Upcoming: CCC 2022 on August 1+2, 2022
Webpage: CCC 2022 Online Conference

Countercurrent Chromatography (CCC) and Partition Chromatography are Countercurrent Separation (CCS) Techniques

Inspired by Craig's countercurrent distribution (CCD), the two most-practived modern countercurrent separation (CCS) techniques are (high-speed) countercurren chromatography ([HS]CCC) and partition chromatography (CPC). Owing to the fact that well-established experimental and instrumental setups exist for HSCCC and CPC that do not use true countercurrent flow of liquids, partition chromatography is the more generic term and actually describes the underlying principle of partitioning the analytes between two immiscible liquid phases. The immense separation power of CCC/CPC results from the following unique poperties:

  • As only solvents are involved and solid supports are avoided, irreversible adsorption cannot occur, sample degradation is minimized, and a theoretical 100% sample recovery is achievable.

  • The partition coefficient, K, is an intrinsic physicochemical constant of each molecular species, which can be used to target CCS analysis for individual compounds

Countercurrent Research at UIC Chicago

Our natural products group at UIC has an extensive track record and expertise in applying and developing CCC experimental techniques.

Countercurrent Chromatography: Background

Countercurrent Chromatography: Resources

Droplets in DCCC


International CCC Conference
CCC 2016

August 1-3, 2016
Dominican Univ. River Forest, IL

K Power = Targeting Compounds by their K Values: Ginkgotoxin Analysis by CS without identical reference standards

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TLP is currently being migrated. Pleas stay tuned.

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Coils and Step Gradients
Droplets in DCCC
Coils and Step Gradients

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