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Countercurrent
Chromatography (CCC) and Countercurrent Separation (CS)
Named
after Craig's renowned countercurrent
distribution (CCD),
chromatographic liquid-liquid separation techniques are commonly referred to as
countercurrent
or partition chromatography
(CCC, CPC).
Owing to the fact that routine experimental setups such as HSCCC
and CPC
do not use true countercurrent flow of liquids, partition chromatography
is the more generic term and actually describes the underlying principle
of partitioning
the analytes between two immiscible liquid phases.
This also illustrates the particular power of
CCC/CPC.
- As only solvents are involved and solid supports
avoided, irreversible adsorption cannot occur,
sample degradation is minimized, and a theoretical
100% sample recovery is achievable.
- The partition coefficient, K, is an important physicochemical constant of each molecular species, which can be used to target its analysis
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Upcoming International CCC Conferences:
CCC 2020 will take place in Chengdu, China,
August 19-21, 2020 (workshop Aug 17+18)
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Countercurrent
Research at UIC Chicago Our natural
products group at UIC has an extensive track record and expertise
in applying and developing CCC experimental techniques. |
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Countercurrent
Chromatography: Background Countercurrent
Chromatography: Resources
- Applications:
compound classes,
GUESS and solvent
system selection, separation
modes, modelling, and chiral CCC/CPC
- Support & Guidelines :
general guidelines,
modes &
types of CCC experiments, instrument
types, manufacturers and
distributors, and links
- Literature:
general
literature, research
articles, and literature
trends
- Countercurrent Separation review articles covering CCC, CPC, HSCCC, and CCS:
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Questions?
Visit the CCC Information Portal |
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TLP is currently being migrated.
Pleas stay tuned.
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eMail
to webmaster
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