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Mission

Gain understanding of the small molecules of life on Earth.

Research

CENAPT|Center for Natural Product Technologies
qNMR
|Quantitative NMR
HiFSA|HiFSA-qNMR
qNMR Calculations
qREF|Botanical Reference Materials
Residual Complexity|IMPs
Dreiding Exchange|Model Kits

Countercurrent Separation CCS/CCC/HSCCC/CPC
CCC 2016|The CCS Conference

Publications|DOIs & Links
Publication Data| Dataverse
Research Topics| Pub Topics

NAPRALERT database
NaProLog

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Learning

Pharmacognosy PhD|
Graduate Program
Courses
|Pharmacy Pharmacognosy
Laboratory Safety

Farnsworth Lectures

 

Overview

Secondary metabolites from natural sources across the phylogenetic tree have always played an important role in physiology, biochemistry, pharmacology, drug discovery and pharmaceutical analysis. Their separation, analysis and pharmacological evaluation are core elements of modern pharmacognosy, representing an interdisciplinary field of research.
Gaining a more holistic insight into the overwhelming complexity of the total pool of secondary metabolites produced by any single organism (metabolome) requires development of innovative (bio)-analytical methodology, such as loss-free and high-resolution countercurrent separation and chromatography (CCS/CCC), quantitative NMR (qNMR), and other innovative spectroscopic (NMR, LC/GC-MS) as well as computational methods developed in our laboratory.
This requirement continues to hold for those metabolites that today are classified as 'small molecules', which open the door to an incredibly large and very important part of nature's chemical space. The design of innovative separation technology and spectroscopic methods for structural analysis and determination of purity and residual complexity, combined with qualitative and quantitative analysis of bioactive principles and their in-depth biological evaluation, are important aspects of secondary metabolome research. Such bio-analytical contributions can advance interdisciplinary research projects and create new insights of biomedical relevance, which can impact current practice and future paradigms in contemporary healthcare research.

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