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Mission

Gain understanding of the small molecules that enable life on Earth

Research

CENAPT|Center for Natural Product Technologies
qNMR
|Quantitative NMR
HiFSA|HiFSA-qNMR|QM-qHNMR
qNMR Calculations
qNMR Summits|Conferences on putting the q into NMR
qREF|Botanical Reference Materials
Residual Complexity
IMPs|Invalid Metabolic Panaceas
Dreiding Exchange|Model Kits

Countercurrent Separation CCS/CCC/HSCCC/CPC
CCC 2016|The CCS Conference

Publications|DOIs & Links
Publication Data|Dataverse
Research Topics|Pub Topics

NAPRALERT database
PCRPS|NaProLog |WHOTRMCC

Photo Galleries

Learning

Pharmacognosy PhD|
Graduate Program
Courses
|Pharmacy Pharmacognosy
Farnsworth Lectures | The Farnsworth Legacy at the UIC College of Pharmacy

Laboratory Safety

 

Overview

Metabolites from natural sources across the phylogenetic tree have always played an important role in pharmacy, physiology, biochemistry, pharmacology, drug discovery and medicine. Their separation, chemical analysis, and pharmacological/biological evaluation are core elements of modern pharmacognosy, representing a highly interdisciplinary field of research.
Gaining a more holistic insight into the overwhelming complexity of the total pool of metabolites produced by any single organism (metabolome) requires the development of innovative (bio)-analytical methodology. To this end, contributions from our laboratory involve the advancement of loss-free and high-resolution countercurrent separation and parition chromatography (CCS/CCC/CPC), and pioneering developments in quantitative NMR (qNMR) for natural product analysis. We also develop other innovative spectroscopic (NMR, LC/GC-MS) as well as computational methods.
Solving analytical puzzles continues to be a challenge
for those metabolites that today are classified as 'small molecules' or designated as 'secondary metabolites'. These organic compound open the door to an incredibly large and very important part of nature's chemical space. The design of innovative separation technology and spectroscopic methods for structural analysis and determination of purity and residual complexity, combined with qualitative and quantitative analysis of bioactive principles and their in-depth biological evaluation, are important aspects of secondary metabolome research. Such bio-analytical contributions can advance interdisciplinary research projects and create new insights of biomedical relevance, which can impact current practice and future paradigms of contemporary healthcare research.

 

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