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Gain understanding of the small molecules that enable and guide life on Earth


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Publication Data|Dataverse
Research Topics|Pub Topics
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Pharmagonosy Institute NAPRALERT|NCI PDQ

Dental Biomaterials & Plants|CENAPT
qNMR|Quantitative NMR
qNMR Calculations
qNMR Summits|Put-q-into-NMR
Botanical Center Botanical Reference|qREF
Residual Complexity
IMPs|Invalid Metabolic Panaceas
Dreiding Exchange|Model Kits
Countercurrent Separation CCS/CCC/HSCCC/CPC

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Mansukh Wani Tribute

Lab Safety | Research Training T32 K12 | PCRPS |Farnsworth Lectures | Atkins Garden|Garden Walk
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Metabolites from natural sources across the phylogenetic tree have always played an important role in pharmacy, physiology, biochemistry, pharmacology, drug discovery and medicine. Their separation, chemical analysis, and pharmacological/biological evaluation are core elements of modern pharmacognosy, representing a highly interdisciplinary field of research.
Gaining a more holistic insight into the overwhelming complexity of the total pool of metabolites produced by any single organism (metabolome) requires the development of innovative (bio)-analytical methodology. To this end, contributions from our laboratory involve the advancement of loss-free and high-resolution countercurrent separation and parition chromatography (CCS/CCC/CPC), and pioneering developments in quantitative NMR (qNMR) for natural product analysis. We also develop other innovative spectroscopic (NMR, LC/GC-MS) as well as computational methods.
Solving analytical puzzles continues to be a challenge
for those metabolites that today are classified as 'small molecules' or designated as 'secondary metabolites'. These organic compound open the door to an incredibly large and very important part of nature's chemical space. The design of innovative separation technology and spectroscopic methods for structural analysis and determination of purity and residual complexity, combined with qualitative and quantitative analysis of bioactive principles and their in-depth biological evaluation, are important aspects of secondary metabolome research. Such bio-analytical contributions can advance interdisciplinary research projects and create new insights of biomedical relevance, which can impact current practice and future paradigms of contemporary healthcare research.


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