Publication Topics | gfp@uic.edu

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Publication Topics: #5:Invalid Metabolic Panaceas (IMPS) || #4:qHNMR as Universal Purity Assay || #3:2D Barcoding of Molecules by NMR || #2:Full Spin Analysis (HiFSA)-qNMR || #1:Actaea/Cimicifuga Triterpene Dereplication

Publications: Access our List of Publications here.

Research Topcis: for additional information about certain aspects of our natural products research, see the Research Topics page.

Publication Topics with Summaries (Reverse Chronology)

Publication Topic #5: Inavalid Metabolic Panaceas IMPS in Natural Products Research and Drug Discovery

• Discovery of a group of well-know natural products that are over-studied and are improbably lead structures for drugs
• Related Publications:
  • JB Friesen, Y Liu, SN Chen, J McAlpine, G Pauli
    Selective Depletion and Enrichment of Constituents in
    “Curcumin” and Other Curcuma longa Preparations
    Journal of Natural Products 82, 621-630 (2019)
    dx.doi.org/10.1021/acs.jnatprod.9b000020 [Open Access Article]
  • K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
    The Essential Medicinal Chemistry of Curcumin
    Journal of Medicinal Chemistry 60, 1620-1637 (2017)
    dx.doi.org/10.1021/acs.jmedchem.6b00975
    PubMedCentral: PMC5346970 [Open Access Article]
  • K. Nelson, J. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
    Curcumin May (Not) Defy Science
    ACS Medicinal Chemistry Letters, 8, 467-470
    http://dx.doi.org/10.1021/acsmedchemlett.7b00139
  • Bisson J, McAlpine J, Friesen JB, Chen SN, Graham J, Pauli GF
    Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
    Journal of Medicinal Chemistry 59: 1671-1690 (2016)
    dx.doi.org/10.1021/acs.jmedchem.5b01009 [Open Access Article]

Publication Topic #4: Quantitative 1H NMR as Universal Purity Assay in Medicinal, Organic and Natural Products Chemistry

• The practically universal nature of quantitative 1H NMR offers great perspectives for its use as routine purity assay
• Related Publication:
  Pauli GF, Chen SN, Simmler C, Lankin D, Goedecke T, Jaki B, Friesen JB, McAlpine J, Napolitano J
  The Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
  Journal of Medicinal Chemistry 57: 9220-9231 (2014)
  dx.doi.org/10.1021/jm500734a
  ADDITIONAL INFO: Topic Page for this paper
  PRACTICAL SUPPORT: Spreadsheet Calculations for qHNMR Analyses

Publication Topic #3: 2D Barcoding of Molecules by NMR

• Demonstrates how 2D NMR cross peak patterns can be utilized as barcodes to identify and elucidate compound classes rapidly and reliably by means of statistical analysis
• Related Publication:
  Part 22- Residual Complexity of Bioactive Natural Products
  Qiu F, McAlpine J, Lankin D, Burton I, Karakach T, Chen SN, Pauli GF
  2D NMR Barcoding and Differential Analysis of Complex Mixtures for Chemical Identification: the Actaea Triterpenes
  Analytical Chemistry 86: 3964-3972 (2014)
  dx.doi.org/10.1021/ac500188j

Publication Topic #2: Full Spin Analysis and Quantitative 1H NMR (qHNMR) for Botanical Analysis

• Quantum mechanical 1H NMR fingerprints of organic molecules can be used to identify and quantify multiple constituents in complex mixtures simultaneously
• Related Publication:
  Napolitano J, Gödecke T, Rodriguez Braso MF, Jaki BU, Chen SN, Lankin D, Pauli GF
  The Tandem of Full Spin Analysis and qHNMR for the Quality Control of Botanicals Exemplified with Ginkgo biloba
  Journal of Natural Products, 75: 238-248 (2012)

Publication Topic #1: Dereplication of Actaea Triterpenes

• A systematic approach to the highly diverse and structurally closely related cycloartenol triterpenes from the popular botanical dietary supplement, Black Cohosh (Actaea racemosa, syn. Cimicifuga racemosa)
• Related Publication:
  Qiu F, Imai A, McAlpine J, Lankin D, Burton I, Karakach T, Farnsworth N, Chen SN, Pauli GF
  Dereplication, Residual Complexity and Rational Naming – the Case of the Actaea Triterpenes
  Journal of Natural Products,75: 432-443 (2012) [http://dx.doi.org/10.1021/np200878s]

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